Chronic rhinosinusitis
ICD-10 J32 · ICD-11 CA0A

Treatment of Chronic Rhinosinusitis with Nasal Polyps in the Nasal Cavity

Chronic rhinosinusitis with nasal polyps in the nasal cavity is a recognised phenotypic subtype that calls for a specific treatment strategy distinct from non-polypoid disease.

Clinical scenario:Chronic rhinosinusitis with nasal polyps present in the nasal cavity. Whether or not polyps are present is a key phenotypic distinction that directly guides treatment selection.

Treatment approach

Management in this setting may include a targeted biologic intervention directed at a specific inflammatory pathway. The full treatment sequence — including eligibility criteria, escalation steps, and monitoring — is available in the complete protocol.

Clinical goals:Reduction in nasal congestion, reduction in polyp size, and improvement in sense of smell.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1503/cmaj.241101

The phenotypic distinction of whether or not the patient has polyps can guide treatment.

Monoclonal antibody therapies are a treatment option for patients with severe chronic rhinosinusitis with nasal polyps recalcitrant to first-line therapies.

Several monoclonal antibody therapies, also known as biologics, can improve both symptoms and signs among patients with severe chronic rhinosinusitis with polyps.

Therapeutic effects include reduction in nasal congestion, reduction in polyp size, improvement in smell and disease-specific quality-of-life score, and minimization of the need for oral steroids and surgical revisions.

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