Chronic pelvic pain syndrome
ICD-10 R10.2 · ICD-11 MG30.00

Treatment of Chronic Pelvic Pain Syndrome in Male Patients with Unilateral Chronic Scrotal Content Pain

Chronic scrotal content pain (CSCP) — also referred to as chronic orchialgia or chronic testicular pain — is unilateral scrotal pain that interferes with activities of daily living and has persisted for more than three months. This protocol addresses the structured management approach for male patients who present in this way.

Clinical Scenario

The protocol targets male patients with unilateral scrotal pain of at least three months' duration that significantly disrupts daily activities. Clinicians should consider this diagnosis when unilateral chronic scrotal pain is present without other pelvic pain sites or urinary symptoms.

Clinical Goals

Meaningful reduction in scrotal pain and improvement in quality of life.

Treatment Approach — Partial Overview

Management is multimodal, integrating conservative lifestyle measures with pharmacologic pain management. For appropriate candidates, procedural options are also part of the framework. The sequencing of interventions, specific agent selection, and procedural criteria are detailed in the full protocol.

Complete regimen — including step-by-step guidance and clinical decision points — is available via the protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1097/JU.0000000000004564

  1. CSCP or chronic testicular pain or chronic orchialgia is defined as unilateral scrotal pain interfering with activities of daily living that has persisted for greater than three months of time.
  2. Clinicians should consider the diagnosis of CSCP in patients who experienced unilateral chronic scrotal pain in the absence of other pelvic sites of pain or urinary symptoms.
  3. Multimodal therapy to pain management is recommended.
  4. Clinicians should discuss lifestyle modification that may improve symptoms and implement as feasible.
  5. In patients with CSCP, clinicians may prescribe pharmacologic pain management agents such as acetaminophen, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, gabapentinoids, and non-opioid options after counseling patients on the risks and benefits.
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