Chronic liver failure
ICD-10 K72.1 · ICD-11 DB99.8

Treatment of Chronic Liver Failure with Hepatopulmonary Syndrome in Chronic Liver Disease with Portal Hypertension

This protocol addresses patients with chronic liver disease and portal hypertension who have developed hepatopulmonary syndrome (HPS) with arterial hypoxaemia — specifically an arterial PaO₂ below 60 mmHg.

Clinical Situation

Hepatopulmonary syndrome is a serious pulmonary complication arising in the setting of chronic liver disease with portal hypertension. When oxygenation falls to a PaO₂ below 60 mmHg, the clinical urgency increases substantially and specific evaluation and management decisions are required.

Treatment Approach

For patients meeting these criteria, management centres on a specific surgical intervention — the only modality that has been demonstrated to be effective for HPS in this setting.

The complete structured protocol — including patient selection criteria, evaluation pathway, and full clinical algorithm — is available via the link below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.jhep.2018.03.024

Patients with HPS and PaO₂ <60 mmHg should be evaluated for LT since it is the only treatment for HPS that has been proven to be effective to date (II-2;1).

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