Retreatment of Chronic Hepatitis C in Children and Adolescents After Prior HCV Therapy Failure

Children and adolescents with chronic hepatitis C infection who previously received HCV therapy and did not achieve a sustained response. Prior therapies that define this retreatment scenario include:

• Interferon-based regimen
• Sofosbuvir
• NS3/4A protease inhibitor
• NS5A inhibitor

Retreatment regimen selection is guided by which specific agents were used in the prior failed therapy — particularly whether an NS3/4A protease inhibitor or NS5A inhibitor was included — and by the presence or absence of cirrhosis.

The complete regimen options, sequencing, and durations are detailed in the full structured protocol below.