Treatment of Chronic Granulomatous Disease When Undergoing an Invasive Procedure
Clinical Scenario
Patients with chronic granulomatous disease (CGD) who are scheduled for an invasive procedure — including sigmoid colonoscopy, upper GI endoscopy, bronchoscopy, or liver/lung biopsy — require specific perioperative management to reduce infection risk.
Antibiotic cover is recommended for all such invasive procedures in CGD patients, given their underlying susceptibility to bacterial infections.
Treatment Approach (Partial Preview)
The protocol involves antibiotic prophylaxis commenced prior to the procedure and continued for a defined period afterwards. The specific agent(s) selected depend on the site of the planned investigation.
Full agent selection, timing, and duration are detailed in the complete structured regimen below.
References
- Antibiotic cover is recommended for all invasive procedures, including sigmoid/colonoscopy, upper GI endoscopy, bronchoscopy and liver/lung biopsy.
- Prophylaxis with Ciprofloxacin (and adding Metronidazole if investigation below the diaphragm is involved) should commence prior to procedure and continue for at least 24 hours afterwards.
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