In patients with chronic granulomatous disease, fever reaching 38°C or above signals a potentially serious acute infection requiring prompt clinical assessment and early intervention.
Febrile illness in a CGD patient carries significant risk. Any febrile episode should be treated promptly with antibiotics, proceeding to appropriate intravenous therapy where necessary.
When a CGD patient with fever does not respond adequately to initial antibacterial therapy, empirical antifungal treatment — in discussion with a specialist centre — becomes part of the clinical picture.
Any febrile illness should be treated promptly with antibiotics, proceeding to appropriate intravenous therapy where necessary.
If a prompt response (within 7–10 days) to antibacterial therapy is not obtained, consideration should be given to commencing empirical antifungal treatment (in discussion with a specialist centre).
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