In patients with chronic granulomatous disease (CGD), a fever of 38 °C or above — or any acute infection — demands prompt clinical action. Early and appropriate antibiotic treatment is central to management.
Febrile illness (temperature of 38 °C or above) or acute infection in a patient with confirmed CGD. Any such episode should be treated promptly with antibiotics, proceeding to appropriate intravenous therapy where necessary.
Oral Ciprofloxacin is recommended as a first-line agent, valued for its spectrum of activity and its capacity to penetrate intracellularly. Specific dosing — including weight-based paediatric dosing and adult dosing — along with escalation criteria, is set out in the full protocol.
Complete regimen and sequencing available via the structured protocol below.
Any febrile illness should be treated promptly with antibiotics, proceeding to appropriate intravenous therapy where necessary.
Oral Ciprofloxacin is a useful first line agent because of its spectrum of activity and capacity to penetrate intracellularly.
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