This protocol covers chondrosarcoma cases that require a more aggressive management strategy: grade 2–3 tumours, clear cell chondrosarcoma, and tumours arising in the pelvis or axial skeleton. Dedifferentiated, mesenchymal, and skull-base variants are outside this protocol’s scope.
Higher-grade chondrosarcomas — including clear cell histology — and all chondrosarcomas arising in the pelvis or axial skeleton are grouped here because they share a requirement for wide-margin resection and, in selected cases, radiation management. This protocol does not apply to dedifferentiated or mesenchymal subtypes, nor to skull-base disease.
Wide-margin surgical resection is the cornerstone of management for these tumours; when margins are limited or resection is not feasible, radiotherapy enters the strategy — the specific sequencing, techniques, and criteria are detailed in the full protocol.
Full regimen, selection criteria, and technique specifications available below ↓
DOI: 10.1038/s41416-024-02868-4
Higher-grade chondrosarcomas (including clear cell chondrosarcoma) and all chondrosarcomas of the pelvis or axial skeleton should be surgically removed with wide margins.
Radiotherapy may be offered for unresectable disease, adjuvantly after surgery for close or positive margins, and for palliation.
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