Cholangiocarcinoma
ICD-10 C22.1 · ICD-11 2C12.0Y

Treatment of Advanced or Inoperable Biliary Tract Cancer (Cholangiocarcinoma) with Adequate Performance Status

This protocol covers the management of cholangiocarcinoma (CCA) in the advanced or inoperable setting, in patients who maintain adequate performance status and are candidates for active treatment.

Clinical Scenario

The patient presents with locally advanced or inoperable biliary tract cancer — a stage at which surgical resection is not feasible. Adequate performance status is a key criterion supporting eligibility for active treatment strategies in this setting.

Treatment Approach (Partial)

For patients with locally advanced inoperable cholangiocarcinoma who have received systemic therapy, specialized radiotherapy approaches — including stereotactic body radiotherapy (SBRT) or proton beam therapy (PBT) — may be considered. The complete patient selection criteria, clinical sequencing, and protocol details are available in the full regimen.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1136/gutjnl-2023-330029

  1. CisGem chemotherapy is recommended as the first-line treatment in patients with advanced BTC.
  2. Combination chemotherapy is recommended in patients with adequate performance status following failure of first-line chemotherapy, particularly in the absence of a targetable molecular alteration.
  3. Consider the delivery of stereotactic radiotherapy (SBRT) or proton beam therapy (PBT) in patients with locally advanced inoperable CCA who have received systemic therapy.
View source ↗