Cervical cancer

ICD-10 C53 · ICD-11 2C77

Treatment of Cervical Cancer — Stage T1b3 or T2a2

Clinical Scenario

This protocol addresses patients with cervical cancer presenting at stage T1b3 or T2a2 — a locally advanced presentation that requires careful consideration of the optimal treatment modality. There is limited evidence to guide the choice between surgical treatment and chemoradiotherapy with image-guided brachytherapy in lymph node-negative patients at these stages.

Treatment Approach

Management of stage T1b3 or T2a2 cervical cancer involves a choice between surgical and radiation-based strategies. Radical surgery is one established option for eligible patients; alternatively, a radiation-based approach combining chemotherapy with brachytherapy may be used. A neoadjuvant strategy is also among the recognised alternatives.

Full regimen details, sequencing, and individualisation criteria are in the complete protocol →

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.ijgc.2025.102747

There is limited evidence to guide the choice between surgical treatment vs chemoradiotherapy with image-guided brachytherapy in lymph node negative patients with T1b3 and T2a2 tumors.
Type C radical hysterectomy is recommended.
Radical surgery composed of radical hysterectomy (preferably type C) with systematic pelvic lymphadenectomy (with sentinel lymph node detection if possible) is an option.
Neoadjuvant chemotherapy followed by radical surgery is an alternative option.

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