In microinvasive cervical cancer at FIGO stage IA1 with no lymphovascular space invasion (LVSI), the limited extent of disease and the absence of LVSI together define a specific clinical scenario for which a structured, evidence-based surgical approach applies.
Cervical cancer classified as FIGO stage IA1 — the earliest microinvasive stage — in patients with no lymphovascular space invasion confirmed. This absence of LVSI is a key criterion that guides the therapeutic strategy and allows consideration of less extensive surgical options.
Surgical management is the primary approach in this setting. The specific procedure chosen depends in part on whether the patient wishes to preserve fertility, with distinct options available for each situation.
The complete structured protocol — including specific surgical criteria, decision criteria, and the conditions under which conservative surgery may represent definitive treatment — is available via the full regimen.
DOI: 10.1093/annonc/mdx220
Microinvasive cervical cancer (stage IA1) without LVSI can be managed with conisation or simple trachelectomy to preserve fertility [I, B].
According to most international guidelines, the first diagnostic and curative step for microscopic tumours is conisation.
Simple hysterectomy can be offered if the patient does not wish to preserve fertility.
In the presence of negative margins and the absence of clinical contraindications to surgery, the cone biopsy may represent definitive treatment.
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