Treatment of Cerebral Meningioma in WHO Grade 2 (Atypical) Disease
Clinical Scenario
This protocol addresses patients with cerebral meningioma classified as
WHO grade 2 (atypical). In this setting, therapy is mandatory —
the atypical grade carries a distinct clinical course that necessitates active
intervention rather than watchful waiting.
Treatment Approach (Partial Overview)
A surgical approach is the primary intervention in this setting, pursued with the aim
of both securing tissue for definitive diagnosis and addressing mass effect. The
quality and extent of resection carry clinical significance in this grade.
The complete treatment sequence, decision criteria, and all remaining protocol
details are available via the link below.
Clinical Goals
Successful management targets relief of neurological symptoms and mass
effect, alongside provision of adequate tissue for histopathological
diagnosis.
References
- In meningioma WHO grade 2, therapy is mandatory.
- To gain tissue for the diagnosis and remove mass effect, surgery is the first option.
- Resection according to Simpson grade I should be achieved.
- Successful surgery achieves 2 goals—relief of neurological symptoms and mass effect and provision of tissue for diagnosis.
DOI: 10.1093/neuonc/noab150
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