Treatment of Recurrent Intracranial Ependymoma in Adults and Children

Intracranial ependymoma can recur after initial treatment in both adult and paediatric patients. When disease recurs, selecting the appropriate next step requires careful consideration of the patient's performance status, age, and prior treatment history.

Clinical Scenario

This protocol addresses recurrent intracranial ependymoma in adults or children — patients in whom the tumour has returned following prior management. The approach differs meaningfully between adult and paediatric populations.

Treatment Approach (Summary)

When local treatment options are no longer applicable, systemic chemotherapy may be warranted — particularly in patients with a good performance status. The specific agents considered depend on patient age and on what therapies have been used previously.

Full regimen details, agent selection criteria, and sequencing are available in the complete protocol.

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References

DOI: 10.1093/neuonc/nox166

Key recommendations for the treatment of recurrent intracranial ependymomas in adults and children
In patients with recurrent ependymomas who are no longer eligible for local treatments, chemotherapy might be warranted, particularly in patients with a good performance status.
In adults, either platinum compounds or temozolomide (based on a more favorable toxicity profile) should be considered.
In children, the choice of chemotherapeutic drugs depends on previous exposures.

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