Cerebral ependymoma
ICD-10 C71.9 · ICD-11 2A00.0Y&XH1511&XA9738

Treatment of Newly Diagnosed Localized Cerebral Ependymoma in Children Older Than 18 Months

This protocol applies to children older than 18 months presenting with a newly diagnosed, localized intracranial ependymoma — confirmed as WHO grade II or III — with no evidence of CSF or spinal dissemination at staging.

Clinical Scenario

Child older than 18 months  ·  Newly diagnosed intracranial ependymoma  ·  WHO grade II or III  ·  Localized — no CSF or spinal dissemination

Treatment Approach — Overview

Management begins with surgical intervention aimed at establishing a definitive histological diagnosis. The extent of tumour removal at surgery is a central consideration, and the approach is guided by intraoperative findings and postoperative imaging. Structured criteria determine when a further surgical step should be considered. The complete protocol — covering the full decision pathway and subsequent management — is accessible below.

Primary Clinical Goal

Gross total resection with no residual tumour visible on postoperative MRI.

Instant Access to Structured Evidence-Based Regimens

References

  1. Key recommendations for the treatment of newly diagnosed intracranial WHO grades II and III ependymomas in children
  2. Resection is recommended to obtain a histological diagnosis and should be a gross total resection whenever feasible.
  3. A second-look surgery should be considered when residual tumor is demonstrated on postoperative MRI and gross total resection is a realistic goal.
  4. Postoperative MRI should be performed to evaluate the extent of resection.

DOI: 10.1093/neuonc/nox166

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