Central Sleep Apnoea Persisting After Optimisation of the Underlying Disorder

Central sleep apnoea (CSA) may arise secondary to another medical condition. In those cases, the first clinical step is to address the primary disorder — but when that is insufficient, a further targeted approach is required.

Clinical Scenario

Secondary CSA due to another disorder (stroke, renal disease). The apnoea is driven by the primary condition yet persists as a distinct clinical problem, even after the underlying disorder has been actively managed.

Previous step that did not achieve the goal: Optimisation of the underlying medical condition — the standard first approach — with the aim of resolving the central sleep apnoea. When that goal is not reached and CSA continues, the protocol below defines the next clinical step.

Next-Line Approach

When the underlying condition has been optimised and central sleep apnoea persists, a trial of device-based positive airway pressure therapy may be considered. Which specific modality is selected — and the clinical conditions that govern its use — are set out in the full structured protocol.

References

  • Secondary CSA due to another disorder (stroke, renal disease).
  • There are several CSA-specific therapies available, both pharmacological and non-pharmacological, that target one or more of the CSA pathophysiologies.

DOI: 10.1183/20734735.0235-2023

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