Treatment of Cardiac Glycoside Toxicity with Severe Hypokalaemia (Serum Potassium <2.5 mmol/L)

Clinical scenario

This protocol addresses cardiac glycoside toxicity in patients who have severe hypokalaemia — specifically a serum potassium below 2.5 mmol/L in the setting of digoxin toxicity. This specific electrolyte finding shapes the management approach.

Specific condition

Severe hypokalaemia (serum potassium <2.5 mmol/L) in digoxin toxicity requires targeted potassium correction. The clinical goal is normalisation of serum potassium without rebound hyperkalaemia.

Approach

Management involves potassium supplementation with careful monitoring to avoid rebound hyperkalaemia. The complete structured regimen — including the specific method, sequencing, and monitoring parameters — is available in the full protocol.

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References

Severe hypokalaemia (serum potassium <2.5 mmol/L) can be managed with additional potassium, taking care to avoid rebound hyperkalaemia.
Severe hypokalaemia can be managed by intravenous administration of additional potassium.
Potassium levels should be carefully monitored to avoid rebound hyperkalaemia.

DOI: 10.1097/MEJ.0000000000001065 View source ↗