This protocol covers cardiac glycoside toxicity in its most critical presentation: digoxin exposure at a level that is potentially fatal. The clinical priority is rapid intervention to prevent death from arrhythmia.
The patient has sustained digoxin exposure sufficient to be life-threatening. This places the presentation at the highest acuity category of cardiac glycoside toxicity, where immediate, targeted treatment is required.
Reversal of life-threatening arrhythmias due to digoxin toxicity.
First-line management involves a specific immune-based therapy directed against digoxin. When this therapy is not immediately accessible, an alternative temporizing approach may be used in a defined subset of patients. The complete regimen, eligibility criteria, and sequencing are in the full structured protocol.
DOI: 10.1016/j.amjmed.2024.08.018