This protocol applies to patients with a well-differentiated appendiceal neuroendocrine tumor (NET, grade G1 or G2) measuring less than 1 cm in diameter where complete (R0) resection has been achieved.
The defining features of this scenario are low-grade histology (G1–G2), tumor size under 1 cm, and confirmed R0 resection status — all of which bear directly on the management approach and the extent of surgery required.
Management centres on a surgical resection strategy tailored to the verified resection margin status.
The complete evidence-based regimen — including the specific surgical steps, follow-up criteria, and the full decision algorithm — is available via the structured protocol below.
Simple appendectomy is curative for appendiceal NETs (G1–G2) < 1 cm (if the resection status is R0), whereas RHC with lymph node dissection is recommended in tumors ≥ 2 cm in diameter, based on the high risk of nodal metastases in these cases.
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