Patients with generalized bullous pemphigoid whose disease remains below the controllable level — unresponsive — despite several weeks of intensive therapy combining both topical and systemic corticosteroids.
For this subset of patients, the protocol outlines the use of conventional immunosuppressant agents as the next therapeutic consideration.
Full selection criteria, agent choice, sequencing, and regimen details are available in the structured protocol below.
In the cases of those few patients with generalized disease who remain below the controllable level (unresponsive) despite several weeks of intensive therapy with combined topical and systemic CS, there are the following therapeutic options:
Conventional immunosuppressants (see above) such as methotrexate, azathioprine mycophenolate mofetil may be considered (4.75 ± 0.81).
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