Buccal mucosa cancer presenting at Stage III or Stage IVA represents locally advanced disease. At these stages, a single-modality approach is insufficient — the evidence points toward treatment strategies that combine multiple interventions.

Clinical Scenario

Buccal mucosa cancer at Stage III or Stage IVA — locally advanced disease for which combined modality treatment is the recommended standard of care.

Treatment Approach (partial overview)

Patients at these stages are offered combined modality treatment. The approach draws on surgery, radiotherapy, and chemotherapy — used in various combinations and sequences depending on disease operability and the patient's individual suitability. The full evidence-based protocol, including sequencing and specific options, is available below.

References

DOI: 10.4103/0971-5851.138953

For locally advanced Stage (III–IVA), surgery followed by RT with or without chemotherapy, concurrent chemo-RT, altered fractionation RT schedules, induction chemotherapy, followed by surgery with or without RT are valid treatment options.
Patients should be offered combined modality treatment for these disease stages.
Treatment options include: Surgery, followed by RT with or without chemotherapy, concurrent chemo-RT, altered fractionation RT schedules, induction chemotherapy, followed by surgery with or without RT.

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Treatment of Buccal Mucosa Cancer: Stage III or Stage IVA