Treatment of Bone Metastases in Breast Cancer

Patients with breast cancer who develop bone metastases require prompt, protocol-driven management to reduce the risk of skeletal complications. Guidelines recommend initiating bone-targeted therapy at the time bone metastases are confirmed — regardless of whether the patient has symptoms.

This protocol is for breast cancer patients with confirmed bone metastases. Both symptomatic and asymptomatic presentations are within scope; the presence or absence of symptoms does not alter the recommendation to begin treatment.

Management centres on bone-targeted agents, started at diagnosis and continued throughout the disease course; the full protocol specifies which agents apply, how dosing evolves over time, and the criteria used to guide those decisions.