This protocol addresses benign liver tumors presenting as multiple hepatocellular adenomas (HCA). The distribution and size of lesions across the liver are the key factors that shape the management decision.
In patients with multiple hepatocellular adenomas, management is guided by the size of the largest tumour. Determining whether disease is anatomically limited or more widespread is central to selecting the appropriate course of action.
Surgical resection is the primary intervention in this setting, with the scope of surgery determined by the extent of hepatic involvement.
The full protocol — including precise surgical criteria, decision thresholds, and the complete step-by-step algorithm — is available in the structured regimen below.
The management of patients with multiple HCA should be based on the size of the largest tumour (evidence level III, grade of recommendation 2)
Those individuals with unilobular disease can be treated with hepatic resection.
For those with more widespread HCA, resection of the largest adenomas may be an option.
Hepatic resection might be considered in unilobular disease, and in those cases with more widespread HCA, resection of the largest adenomas may be an option (evidence level III, grade of recommendation 2)
DOI: 10.1016/j.jhep.2016.04.001