Treatment of Papillary Fibroelastoma with Left-Sided Cardiac Location or Tumor Diameter >10 mm

Papillary fibroelastoma (PFE) is a benign cardiac tumor whose clinical significance depends heavily on location and size. When a PFE is situated in a left-sided cardiac structure, or when its diameter exceeds 10 mm, the risk of thromboembolic events — including stroke — is meaningfully elevated.

Clinical Scenario

Papillary fibroelastoma with left-sided cardiac location, or tumor diameter larger than 10 mm — features that place the patient at increased stroke risk and determine the management pathway.

Management Approach

In certain cases, antiplatelet therapy may be incorporated into the management strategy, though the supporting evidence for this option remains limited. The full protocol specifies the complete decision pathway and the applicable interventions.

Instant Access to Structured Evidence-Based Regimens

References

For left-sided PFEs or larger than 10 mm, surgical removal is recommended due to the increased risk of stroke.
In cases where surgery is not performed, antiplatelet medications may be considered, although data on this approach are limited.

DOI: 10.1007/s12032-025-02661-0

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