Behçet's disease
ICD-10 M35.2 · ICD-11 4A62

Treatment of Behçet's Disease with Confirmed Gastrointestinal Involvement

This protocol applies to Behçet's syndrome in which gastrointestinal involvement has been confirmed by endoscopy or imaging, and where other causes of similar findings have been systematically excluded.

Clinical Scenario

Gastrointestinal involvement in Behçet's syndrome must be confirmed by endoscopy and/or imaging before this protocol applies. NSAID-related ulcers, inflammatory bowel disease, and infections including tuberculosis should be ruled out first.

Treatment Approach — Partial Overview

Acute exacerbations are typically managed with corticosteroid-based therapy alongside disease-modifying agents. Certain urgent presentations require immediate surgical evaluation.

The complete regimen — including agent selection, sequencing, and escalation criteria — is available in the full structured protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1136/annrheumdis-2018-213225

Gastrointestinal involvement of BS should be confirmed by endoscopy and/or imaging.

NSAID ulcers, inflammatory bowel disease and infections such as tuberculosis should be ruled out.

Glucocorticoids should be considered during acute exacerbations together with disease-modifying agents such as 5-ASA or azathioprine.

Urgent surgical consultation is necessary in cases of perforation, major bleeding and obstruction.

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