Behçet's Syndrome with Acute Sight-Threatening Uveitis: Treatment Approach
Acute sight-threatening uveitis in Behçet's syndrome is an ocular emergency. Initial and recurrent episodes both carry a risk of irreversible visual impairment without timely, effective systemic intervention.
Clinical scenario
Patients with Behçet's syndrome presenting with an initial or recurrent episode of acute sight-threatening uveitis — a situation requiring urgent systemic management to preserve vision.
Treatment overview
Management centres on systemic high-dose glucocorticoids combined with a targeted immunomodulatory agent. For certain unilateral presentations, an additional local option may be used alongside systemic therapy. The complete regimen and clinical decision pathway are detailed in the full protocol.
References
DOI: 10.1136/annrheumdis-2018-213225
- Patients presenting with an initial or recurrent episode of acute sight-threatening uveitis should be treated with high-dose glucocorticoids, infliximab or interferon-alpha.
- Intravitreal glucocorticoid injection is an option in patients with unilateral exacerbation as an adjunct to systemic treatment.
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