Treatment of Recurrent or High-Risk Basal Cell Carcinoma
Certain clinical and histopathological features place a basal cell carcinoma in a high-risk category that requires a distinct treatment strategy. This protocol addresses those presentations specifically.
Clinical Scenario
- Recurrent basal cell carcinoma
- Aggressive histopathological subtype
- Located on a critical anatomical site
- Poorly defined margins
- Perineural invasion
- Multiple basal cell carcinomas
Treatment Approach
For high-risk BCC presentations, the protocol includes an oral hedgehog pathway inhibitor as a systemic treatment option. The specific agent, selection criteria, and full management details are available in the complete protocol below.
References
DOI: 10.1016/j.ejca.2023.113254
- Micrographically controlled surgery shall be offered in high-risk and recurrent BCC, and BCC located on critical anatomical sites.
- Micrographically controlled surgery (3D) shall be offered in high-risk BCC (recurrent, aggressive subtypes, location in critical anatomical sites, poorly defined margins)
- Hedgehog inhibitors should be offered to patients with locally advanced or metastatic BCC