What Is the First-Line Treatment for Barrett's Esophagus?
Treatment approach
For patients with Barrett's esophagus without contraindications to the recommended therapy, first-line management centres on proton pump inhibitor (PPI) therapy. The specific dosing schedule, criteria for adjustment, and the complete evidence-based algorithm are set out in the full protocol →
References
DOI: 10.14309/ajg.0000000000001680
- We suggest at least once-a-day PPI therapy in patients with BE without allergy or other contraindication to PPI use (strength of recommendation: conditional; quality of evidence: very low).
- Given the unclear benefit of higher doses of PPI on oncogenesis, the panel recommended at least daily dosing, with higher doses considered for those requiring them for symptom control.
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