Endogenous bacterial endophthalmitis arises from haematogenous spread of bacteria to the eye. When it occurs in the setting of concomitant bacteremia, the therapeutic strategy must address both the intraocular infection and the systemic source simultaneously.
This protocol is specifically designed for patients with endogenous bacterial endophthalmitis who also have concomitant bacteremia.
Management involves direct intravitreal antibiotic injection together with systemic antibiotic therapy — the systemic component is indispensable in the context of concurrent bacteremia. An adjunctive agent is frequently incorporated as well. The complete agent selection, combinations, and sequencing are available in the full protocol.
DOI: 10.1128/CMR.15.1.111-124.2002
The recommended management of bacterial endophthalmitis includes direct injection of antibiotics into the vitreous.
Systemic antibiotics remain an integral part of the therapeutic approach to endogenous endophthalmitis where there is concomitant bacteremia.
Despite these conflicting results, dexamethasone is frequently used as an adjunct to antibiotic therapy in endophthalmitis.
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