Treatment of Autoimmune Metaplastic Atrophic Gastritis: Nutritional Deficiency Prevention
Autoimmune metaplastic atrophic gastritis (AMAG) leads to impaired absorption of key micronutrients. Management at early stages centres on preventing the deficiencies that follow — particularly involving vitamin B12, folate, and iron — before downstream complications develop.
Treatment approach
The structured protocol involves targeted nutritional supplementation to address the specific deficiencies arising from AMAG. Oral vitamin B12 replacement plays a central role, with particular considerations depending on the degree of mucosal atrophy. Other micronutrients are monitored and supplemented according to individual deficiency status. Full dosing guidance, monitoring intervals, and the complete evidence-based regimen are in the protocol…
References
- The management strategies of the early stages of autoimmune atrophic gastritis is focused on the prevention of vitamin B12, folate and iron deficiencies.
- Adequate supplementation of these substances will effectively prevent vitamin B12 depletion and the development of anemia.
- High replacement doses, orally, of 500 to 1,000 μg a day seem to be effective in case of little atrophy.
- Other micronutrient deficiencies, folate or 25-OH vitamin D, should be regularly checked, since they have been reported in AMAG patients.
- In case of deficiency of these micronutrients, specific supplementation is indicated.
DOI: 10.14309/ajg.0000000000002968
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