This protocol applies to patients with atrial septal defect presenting with an intermediate elevation in pulmonary vascular resistance alongside a haemodynamically significant left-to-right shunt.
In this specific haemodynamic context, a structural intervention directed at the septal defect itself is the approach outlined in the evidence-based protocol. The full regimen — including procedural criteria, sequencing, and case-specific considerations — is available via the link below.
DOI: 10.1093/eurheartj/ehaa554
In patients with PVR 3–5 WU, ASD closure should be considered when significant LR shunt is present (Qp:Qs >1.5).
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