فقر الدم الانحلالي المناعي الذاتي الدافئ: ماذا تفعل عندما لا يستقر الهيموغلوبين بعد العلاج بالكورتيكوستيرويد

References

DOI: 10.1182/hematology.2022000405

• If the patient is severely affected or shows no response within 2 weeks, rituximab should be given at a dose of either 375mg/m² for 4 weeks or 2 separate weekly doses of 1000mg each.
• Standard doses of 375mg/m² weekly for 4 weeks or 2 doses of 1000mg 2 weeks apart have been studied.
• Corticosteroids are weaned slowly over 8 to 12 weeks, and if an adequate therapeutic response (eg, Hgb over 9-10 g/dL) cannot be maintained at a dose of prednisone less than or equal to 5mg/d, rituximab (if not already given) is administered.
• A complete response (CR) was defined as normalization of Hgb, no evidence of hemolysis (normal bilirubin, LDH, haptoglobin, and reticulocytes), and the absence of transfusions.