ما هو العلاج الخط الأول للفشل التنفسي غير المحدد؟

References

DOI: 10.1186/s40560-023-00658-3

• As a recent network meta-analysis demonstrated decreased survival in patients with a PaO2 target of 55–75 mmHg and patients with a PaO2 ≥ 150 mmHg, it seems appropriate to follow the traditional oxygenation strategy that avoids excess hypoxemia and hyperoxemia.
• In these studies, the actual difference between study groups was 15–28 mmHg in PaO2 or 1–4% in SaO2, and PaO2 was maintained between 70 and 110 mmHg in both groups in all studies.
• In the HFNC guidelines by the American College of Physicians, HFNC was weakly recommended for ARF over NPPV due to a systematic review reporting that HFNC for ARF is associated with lower mortality and a lower intubation rate compared to NPPV.
• In ARF, pharmacotherapy should be focused on the underlying disease or diseases that are causing hypoxemia.
• In situations where respiratory infections cannot be ruled out, the use of broad-spectrum antibiotic regimens including a macrolide or new quinolone is often considered.