علاج الخط الأول للساركوما الشكلانية غير المتمايزة

References

DOI: 10.1016/j.ejso.2021.12.008

• Surgery in combination with radiotherapy (sporadically combined with chemotherapy in case of high-risk of development of metastasis) is the common therapy of choice for UPS, which is similar to the treatment of other STS.
• Patients with eUPS were significantly more often treated with limb-sparing surgery compared with other eSTS.
• Patients with R1-R2 margins treated with radiotherapy had about half the risk of developing LR compared with patients who were not treated with radiotherapy.
• Radiotherapy and surgical margins were considered as predictors for local control.
• Surgical margin was also a prognostic factor for DM.
• Margins were defined as follows: free (R0) when no residual tumour was found at the inked surface, marginal (R1) when microscopic residual tumour was found and intralesional (R2) when macroscopic residual tumour was detected.