علاج متلازمة انحلال الورم المختبرية أو السريرية الراسخة

References

1. Adult and paediatric patients with established TLS (laboratory or clinical TLS) should be treated with rasburicase 0.2 mg/kg/day for up to 7 days (although 3–5 days is frequently sufficient) with the exact duration based upon clinical response (1B).
2. Vigorous hydration with intravenous fluid is an essential component of TLS treatment.
3. For adults, a rate of 3 L/m² should be initiated and the ongoing rate adjusted to maintain a urine output of 100 mL/m²/h.
4. In children, a rate of up to 4 L/m² can be given, depending on renal function, clinical and fluid status.
5. The aim is to maintain a urine output of 100 mL/m²/h in adults (1B).