ابيضاض الدم الليمفاوي التائي ذو الحبيبات الكبيرة عند فشل السيكلوسبورين في السيطرة على قلة خلايا الدم

References

DOI: 10.1002/hon.70076

• In many patients however, the cytopenias do not respond to these standard immunosuppressive agents, or the response is lost with time.
• A plethora of other agents have been investigated, often just in a single case or in small retrospective case series as summarized in Table 3.
• JAK inhibitors have more recently been proven to have activity in this condition.
• Ruxolitinib was investigated in 23 patients, and in the 20 patients that were evaluable at the time of reporting the ORR was 55%, with the presence of a STAT3 mutation associated with response.
• 25 patients given alemtuzumab Iv 10 mg for 10 days ORR 56%