علاج الباراغانغليوما الودية لدى الأطفال والمراهقين المصابين بمرض موضعي قابل للاستئصال

References

DOI: 10.1093/ejendo/lvaf239

• Surgical resection is the mainstay of curative treatment for localized pediatric PGL.
• Alpha-adrenergic blockade is the cornerstone of preoperative management and should be initiated at least 7-14 days prior to surgery.
• Volume expansion is vital to reverse chronic vasoconstriction and restore plasma volume.
• The dosing goal is to achieve mild orthostatic hypotension, typically a fall in systolic blood pressure of up to ∼20 mmHg or a diastolic of ∼10 mmHg on standing, while maintaining tolerable supine pressures.