علاج متلازمة الصدمة السمية العقدية: بروتوكول الخط الأول

References

• Penicillin G is bactericidal and remains, at high parenteral doses, the first-line treatment for infections due to SGA.
• Clindamycin, a lincosamide antibiotic, is usually added to penicillin or aminopenicillin since it inhibits the protein synthesis by blocking the 50S sub-unit of the bacterial ribosome.
• Only surgical debridement of infected and necrotic tissues associated with high-dose systemic antibiotic therapy may improve mortality.
• In case of necrotizing fasciitis and/or myositis, this aggressive surgical approach is the only one that may help stabilize the patient and save his life.
• Antibiotic therapy should be given rapidly, associating high doses of parenteral beta-lactams plus clindamycin for its "anti-toxin" effect.