علاج التهاب كبيبات الكلى سريع التقدم في التهاب الكلية الذئبي (التكاثري المنتشر، الدرجة الرابعة)

References

• We recommend immunosuppressive agents (cyclophosphamide or mycophenolate mofetil) with corticosteroids as the initial therapy for patients with diffuse proliferative lupus nephritis.
• In patients with lupus nephritis presenting with RPGN (class IV and some class III cases), the addition of immunosuppressive agents to corticosteroids in the initial therapy has been shown to improve renal function and survival.
• In patients with lupus nephritis presenting with RPGN (class IV and some class III cases), adding intravenous pulse corticosteroid therapy to oral corticosteroids is recommended when the decline of renal function is very rapid, or when severe systemic complications such as pulmonary hemorrhage or central nervous system (CNS) lupus are present.
• The standard protocol in pulse corticosteroid therapy is intravenous administration of 500 mg to 1 g of methylprednisolone for three consecutive days, followed by 0.6–0.8 mg/kg body weight of oral prednisolone.