داء الندوبات الرئوي الخفيف مع أمراض رئوية مزمنة — عندما لا يُحقق TMP-SMX التحسن المطلوب

References

DOI: 10.1093/cid/ciae643

Although no validated grading system for Nocardia severity exists, patients with mild nocardiosis are often managed in the outpatient setting, have a chronic course leading to diagnosis, and have nondisseminated infection.

Additionally, select immunocompetent patients with mild pulmonary nocardiosis (typically those with chronic pulmonary disease) can be closely monitored until susceptibility results are available.

Patients with TMP-SMX toxicity and yet-to-improve severe infection may be better served transitioning to alternative therapy, as patients with severe nocardiosis are underrepresented in the available data.

Patients with pulmonary or CNS disease should undergo follow-up chest or brain imaging, respectively, to evaluate for response to treatment.