داء المخاطيات الرئوي: ماذا تفعل عندما يفشل علاج مضادات الفطريات من الخط الأول في السيطرة على العدوى

References

• Isavuconazole is strongly supported as salvage treatment.
• Posaconazole delayed release tablets or infusions are strongly supported for salvage treatment, and when available should be preferred over posaconazole oral suspension, which in turn is marginally supported for salvage treatment.
• In cases of primary treatment failure with isavuconazole or posaconazole, the guideline group supports recommendations for all three lipid-based amphotericin B formulations with strong to moderate strength.
• In case of extensive disease, rapid progression, or poor general condition, the addition of isavuconazole or posaconazole can be considered.
• The guideline group strongly supports treatment until permanent reversal of immunosuppression and complete response on imaging, which might be difficult to determine because of scarring and postoperative changes.