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References

DOI: 10.1210/jc.2015-1710

We recommend glucocorticoid therapy in all patients with confirmed PAI.

We suggest using hydrocortisone (15-25 mg) or cortisone acetate (20-35 mg) in two or three divided oral doses per day; the highest dose should be given in the morning at awakening, the next either in the early afternoon (2 h after lunch; two-dose regimen) or at lunch and afternoon (three-dose regimen).

We recommend that all patients with confirmed aldosterone deficiency receive mineralocorticoid replacement with fludrocortisone (starting dose, 50-100 µg in adults) and not restrict their salt intake.

General well-being, electrolytes within the normal range, and normal blood pressure without evidence of postural hypotension indicate adequate mineralocorticoid replacement.

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