سرطان القضيب الحرشفي الخلايا مع كتلة عقدة أربية ثابتة أو اعتلال العقد الليمفاوية الحوضية (cN3)

References

• cN3 Fixed inguinal nodal mass or pelvic lymphadenopathy, unilateral or bilateral
• Offer neoadjuvant chemotherapy using a cisplatin- and taxane-based combination to chemotherapy-fit patients with pelvic lymph node involvement or those with extensive inguinal involvement (cN3), in preference to upfront surgery.
• The limited available evidence favours a cisplatin- and taxane-based combination (doublet or triplet) as the preferred preoperative approach.
• A phase II trial evaluated treatment with four cycles of neoadjuvant TIP in patients with clinical N2 or N3 LN metastases.
• Neoadjuvant chemotherapy (NAC) is a reasonable strategy among patients with cN3 disease based on the results of a systematic review which reported radiological response rates of approximately 53% and pathological complete response in approximately 12.8% of patients.