العلاج الأحادي الأولي لمرض باركنسون: أي فئة دوائية يجب البدء بها

References

DOI: 10.1186/s42466-024-00325-4

• Levodopa preparations can be used for PD therapy without prioritization among preparations based on the comprised decarboxylase inhibitor (Carbidopa or Benserazide).
• Non-ergoline dopamine agonists (Pramipexole, Ropinirole, Piribedil, Rotigotine, with limitations Apomorphine) can be used for PD therapy, considering specific indications outlined below.
• MAO-B inhibitors Selegiline or Rasagiline can be used as monotherapy for early PD or in combination with Levodopa for treatment of PD with fluctuations.
• Dopamine agonists or MAO-B inhibitors should therefore be considered preferentially over Levodopa for biologically younger patients.
• However, patients requiring Levodopa in initial monotherapy should of course receive it.