علاج لين العظام بعد جراحة السمنة أو في حالات سوء الامتصاص

Higher daily doses of vitamin D or alternatives routes may be necessary in cases of impaired GI absorption; in these circumstances up to 10,000 − 50,000 I. U. of native vitamin D can be utilized.

Higher amounts in the range of 2000 to 3000 mg daily are needed in patients with malabsorption or after bariatric surgery, although poorly tolerated; this regimen can also reduce kidney stones in patients who have had gastric bypass surgery.

In cases of malabsorption, calcifediol (wherever available) can be utilized because it is a more polar metabolite that is absorbed via the portal system.

Target levels of serum 25OHD should be aimed at maintaining >30 ng/mL and PTH levels within the reference range.

With effective therapy, clinical symptoms begin to improve within a few weeks; however, complete resolution of symptoms may take several months.