علاج لين العظام: مكملات فيتامين د والكالسيوم عن طريق الفم كخط أول للعلاج

References

DOI: 10.1002/jbm4.10447

• Therapy consists of daily oral doses of vitamin D in the range of 800 to 1200 IU.
• Another schedule entails administration of 50 000 IU of native vitamin D weekly for 8 to 12 weeks, followed by a maintenance dose of 1000 to 2000 IU daily.
• Because these regimens may take a long time to reach vitamin D sufficiency, higher loading doses not exceeding 100 000 IU can be utilized based on pharmacological principles.
• Treatment with vitamin D must be always accompanied by adequate calcium supplements.
• One-thousand milligrams of elementary calcium divided in two or three doses is sufficient in most cases.
• Target levels of serum 25OHD should be aimed at maintaining >30 ng/mL and PTH levels within the reference range.
• With effective therapy, clinical symptoms begin to improve within a few weeks; however, complete resolution of symptoms may take several months.