ما هو علاج الحزاز الحلقي الفموي؟

References

DOI: 10.1111/jdv.16464

• Topical application of potent or ultrapotent steroids is the mainstay of treatment in the case of localized OLP.
• Clobetasol propionate 0.05%, triamcinolone, betamethasone, fluocinonide, fluticasone, dexamethasone and prednisolone in different forms have been proved to be effective and safe.
• Usually, twice-daily application of topical steroids for 1-2 months, and then administered as needed, is a common practice.
• Intralesional injection of corticosteroids (triamcinolone acetonide hydrocortisone, dexamethasone and methylprednisolone) in ulcerative OLP is also an effective treatment approach.
• Injections can be painful; to avoid mucosal atrophy, we usually administer a corticosteroid dilution of 10 mg/mL.
• Systemic corticosteroids, methylprednisolone or prednisone (30–80 mg/day) are the most effective treatment modality for patients with diffuse recalcitrant erosive OLP or multisite lesions of severe erosive OLP.
• Systemic retinoids, such as acitretin (25–50 mg/day) initially, followed by isotretinoin (0.5–1 mg/kg/day), have been used in the treatment of OLP.
• Topical retinoids (isotretinoin 0.05–0.1%) or other forms of vitamin A derivatives can eliminate white lesions, but in all cases reported the lesions relapsed 2–5 weeks after discontinuation of treatment.
• Systematic use of cyclosporine (3–10 mg/kg/day) has been found to be effective in different studies and for some authors is considered to be the drug of choice.