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References

DOI: 10.1016/j.ophtha.2025.12.029

• Topical medical therapy is currently the most common initial intervention to lower IOP (see Table 4 for an overview of options available).
• Prostaglandin analogs are the most frequently prescribed eye drops for lowering IOP in patients with glaucoma because they are most efficacious and well tolerated, and they need to be instilled only once daily.
• Therefore, prostaglandin analogs are often selected as initial medical therapy unless other considerations, such as contraindications, cost, side effects, intolerance, or patient refusal preclude this.
• Laser trabeculoplasty surgery may be used as initial or adjunctive therapy in patients with POAG.
• A reasonable initial treatment goal in a patient with POAG is to reduce IOP 20% to 30% below baseline and to adjust up or down as indicated by disease course and severity.