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References

We recommend that oral glucocorticoids be given for 8 weeks (4 weeks of daily glucocorticoids followed by 4 weeks of alternate-day glucocorticoids) or 12 weeks (6 weeks of daily glucocorticoids followed by 6 weeks of alternate-day glucocorticoids).

The standard dosing regimen for the initial treatment of nephrotic syndrome is daily oral prednisone/prednisolone 60 mg/m² per day or 2 mg/kg per day (maximum 60 mg/d) for 4 weeks followed by alternate-day prednisone/prednisolone 40 mg/m² or 1.5 mg/kg (maximum 40 mg) for another 4 weeks or prednisone/prednisolone 60 mg/m² per day or 2 mg/kg per day (maximum 60 mg/d) for 6 weeks followed by alternate-day prednisone/prednisolone 40 mg/m² or 1.5 mg/kg (maximum 40 mg) for another 6 weeks.

SSNS: Complete remission within 4 weeks of prednisone or prednisolone at standard dose.

Complete remission: First morning urine or 24-h uPCR ≤200 mg/g (0.2 g/g or 20 mg/mmol or negative or trace dipstick or <100 mg/m² per day) on three or more consecutive days.