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References

DOI: 10.1177/2514183X1882337

• The serotonin (5-HT)1B/1D-receptor agonists (so-called triptans) almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan are the therapy of first choice in moderate and severe migraine attacks which are not or only insufficiently responsive to therapy with analgesics or non-steroidal anti-inflammatory drugs (NSAIDs).
• Sumatriptan subcutaneous injection (6 mg) is the most effective therapy of acute migraine attacks.
• Eletriptan and rizatriptan are the most effective oral triptans according to results of meta-analyses.
• Triptans are more effective if taken early in the migraine attack or when the headache is still mild.
• If headache recurs after initial effectiveness of a triptan, a second dose of the triptan may not be given for at least 2 h.
• The reduction of headache after 2 h, the most important parameter in clinical studies for the efficacy of migraine medications, is greatest following subcutaneous administration of sumatriptan (70–80%).