علاج التهاب الأوعية المجهري غير المهدِّد للأعضاء عندما يفشل العلاج التحريضي الأولي

References

1. For induction of remission of non-organ-threatening or non-life-threatening GPA or MPA, treatment with a combination of glucocorticoids and rituximab is recommended.
2. For patients with GPA or MPA with disease refractory to therapy to induce remission, we recommend a thorough reassessment of disease status and comorbidities and consideration of options for additional or different treatment.
3. These patients should be managed in close conjunction with, or referred to, a centre with expertise in vasculitis.
4. It may be considered for remission induction in non-organ-threatening disease when the alternatives RTX, MTX and MMF cannot be used or are ineffective.
5. Adding intravenous immunoglobulins can be an option for persistent disease manifestations, particularly in patients with increased risk of infection.